Which granulation method is characterized by creating a cohesive mass that is then blended and dried after passing through sieves?

• A. Dry Granulation
• B. Wet Granulation
• C. Fluid Bed Granulation
• D. NOTA

Answer: (B)

Wet granulation relies on turning powders into a cohesive damp mass by using a granulating liquid. That moist mass is then formed into granules by passing it through sieves to achieve the desired size, and the granules are dried to remove moisture before final blending. This approach is chosen when powders don’t flow or compress well on their own, and a binder is needed to create sturdy granules with uniform content.

Dry granulation, by contrast, uses pressure to create a cohesive mass without any liquid binder, followed by milling; no drying step is involved. Fluid bed granulation is a type of wet granulation conducted in a fluidized bed, where a binder is sprayed while the powder is kept in suspension and granules form as it dries.