Name an anti-seizure drug that induces cytochrome P450 and has teratogenic risk.

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Prepare for the Manor Preboards Module 5 Test with multiple choice questions and detailed explanations. Enhance your study with structured modules to master the test content efficiently.

Multiple Choice

Name an anti-seizure drug that induces cytochrome P450 and has teratogenic risk.

Explanation:
Enzyme induction by some antiseizure medications increases hepatic metabolism by activating cytochrome P450 enzymes, which can lead to drug interactions and, when used in pregnancy, a higher risk of birth defects. Phenytoin is a classic example that induces cytochrome P450 enzymes, boosting its own metabolism and that of other drugs, and it carries teratogenic risk such as fetal hydantoin syndrome. The other options do not have this strong inducing effect: valproate can be teratogenic but inhibits cytochrome P450 rather than inducing it, while lamotrigine and levetiracetam do not meaningfully induce these enzymes.

Enzyme induction by some antiseizure medications increases hepatic metabolism by activating cytochrome P450 enzymes, which can lead to drug interactions and, when used in pregnancy, a higher risk of birth defects. Phenytoin is a classic example that induces cytochrome P450 enzymes, boosting its own metabolism and that of other drugs, and it carries teratogenic risk such as fetal hydantoin syndrome. The other options do not have this strong inducing effect: valproate can be teratogenic but inhibits cytochrome P450 rather than inducing it, while lamotrigine and levetiracetam do not meaningfully induce these enzymes.

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