Excessive use of binders can affect which tablet properties?

• A. Bioavailability
• B. Disintegration
• C. Dissolution
• D. All of the above

Answer: (D)

Binder holds the tablet together, giving it strength, but using too much binder changes how the tablet behaves in the body. When there is excess binder, the tablet becomes harder and less porous, making it harder for water to penetrate. That slows disintegration—the tablet taking apart in the digestive tract. If disintegration is slowed, the drug is exposed to the dissolution medium more slowly, so dissolution—the release of the drug into solution—also slows. For many drugs, especially those poorly soluble or where dissolution controls how much gets absorbed, this slower dissolution reduces bioavailability. Some binders can also interact with the drug or alter wettability, further affecting dissolution and absorption. So excessive binder can impact disintegration, dissolution, and bioavailability all together.