Excessive use of binders affects which of the following tablet characteristics?

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Prepare for the Manor Preboards Module 5 Test with multiple choice questions and detailed explanations. Enhance your study with structured modules to master the test content efficiently.

Multiple Choice

Excessive use of binders affects which of the following tablet characteristics?

Explanation:
Excessive binder makes tablets too cohesive, increasing hardness and reducing porosity, which slows water entry and the tablet’s breakup. That directly impedes disintegration—the first step in releasing the drug. If the tablet disintegrates more slowly, dissolution—the drug entering solution—also slows, especially for poorly soluble drugs. Since bioavailability depends on how much drug actually dissolves and is absorbed, slower dissolution can lower bioavailability. So, too much binder can affect disintegration, dissolution, and ultimately bioavailability, making all of the above the best answer.

Excessive binder makes tablets too cohesive, increasing hardness and reducing porosity, which slows water entry and the tablet’s breakup. That directly impedes disintegration—the first step in releasing the drug. If the tablet disintegrates more slowly, dissolution—the drug entering solution—also slows, especially for poorly soluble drugs. Since bioavailability depends on how much drug actually dissolves and is absorbed, slower dissolution can lower bioavailability. So, too much binder can affect disintegration, dissolution, and ultimately bioavailability, making all of the above the best answer.

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